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Published on: September 27, 2024

[Significance of various methods of assessment of functional state for cardiovascular risk stratification]

Zh D Kobalava, S V Villeval'de, V S Moiseev

    Kardiologiia
    |February 12, 2008
    PubMed

    Insights

    Early detection of kidney damage in patients with arterial hypertension and diabetes is crucial. Monitoring kidney function markers like creatinine and urinary protein can prevent severe cardiovascular outcomes.

    Area of Science:

    • Nephrology
    • Cardiology
    • Endocrinology

    Context:

    • Arterial hypertension (AH) and diabetes mellitus (DM) significantly accelerate kidney damage.
    • Impaired renal function is a major independent prognostic factor for cardiovascular morbidity and mortality.
    • Early intervention is key to preventing or delaying unfavorable outcomes of kidney disease.

    Purpose:

    • To review contemporary methods for early preclinical detection of renal damage in patients with cardiovascular diseases.
    • To highlight the importance of assessing kidney function in patients with AH.

    Summary:

    • Elevated serum creatinine, reduced creatinine clearance, decreased calculated glomerular filtration rate (GFR), and microalbuminuria are critical indicators of kidney impairment.
    • Routine estimation of GFR using the MDRD equation or creatinine clearance via the Cockcroft-Gault formula, alongside urinary protein measurement, is essential for all AH patients.
    • This review consolidates current literature on preclinical renal damage detection methods.

    Impact:

    • Facilitates timely interventions to prevent or delay the progression of kidney disease.
    • Aims to reduce cardiovascular morbidity and mortality associated with comorbid AH and DM.
    • Emphasizes the need for proactive renal function assessment in at-risk patient populations.

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