pH dependence of sulpiride binding to D2 dopamine receptors in bovine brain

In summary then these data suggest that butyrophenones such as spiperone and substituted benzamides such as sulpiride interact with different groups at the active site of the D2 dopamine receptor. The drugs bind in different modes to the receptor which must therefore contain separate but overlapping binding sites for the two classes of drug. Understanding the precise interactions involved that generate this selectivity will be important for drug design.