Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.

Nature communications·2026
Same author

Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.

medRxiv : the preprint server for health sciences·2026
Same author

Worldwide Impact of Human Development and Inequality on the Prevalence of Asthma, Rhinoconjunctivitis and Eczema. Global Asthma Network's Ecological Study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.

Nature·2026
Same author

Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.

Nature·2026
Same author

Icotrokinra induces early and sustained pharmacodynamic responses in phase IIb study of patients with moderate-to-severe psoriasis.

JCI insight·2025

Related Experiment Video

Updated: Jul 7, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

LDL-cholesterol concentrations: a genome-wide association study.

Manjinder S Sandhu1, Dawn M Waterworth, Sally L Debenham

  • 1Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK. manj.sandhu@srl.cam.ac.uk

Lancet (London, England)
|February 12, 2008
PubMed
Summary

This genome-wide study identified a novel locus on chromosome 1p13.3 associated with LDL cholesterol levels. These findings may reveal new therapeutic targets for cardiovascular disease.

Related Experiment Videos

Last Updated: Jul 7, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Area of Science:

  • Genetics
  • Cardiovascular Disease Research

Background:

  • Low-density lipoprotein (LDL) cholesterol is a known contributor to cardiovascular disease.
  • Understanding LDL cholesterol metabolism and regulation is key to identifying new therapeutic strategies.

Purpose of the Study:

  • To conduct a genome-wide association study (GWAS) to identify genetic factors influencing LDL cholesterol concentrations.

Main Methods:

  • Utilized GWAS data from over 11,000 participants across multiple studies.
  • Analyzed hundreds of thousands of single nucleotide polymorphisms (SNPs).
  • Employed meta-analysis and replication studies to validate associations.

Main Results:

  • Identified three significant SNPs (rs599839, rs4970834, rs646776) at the 1p13.3 chromosomal locus associated with LDL cholesterol.
  • Two SNPs (rs599839 and rs646776) explained approximately 1% of LDL cholesterol variation.
  • Each associated allele corresponded to a ~15% standard deviation change in LDL cholesterol.

Conclusions:

  • Provided evidence for a novel LDL cholesterol regulatory locus on chromosome 1p13.3.
  • These genetic insights may illuminate biological pathways for LDL cholesterol regulation.
  • The findings could aid in discovering novel therapeutic targets for cardiovascular disease.