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Updated: Jul 7, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Solid-liquid interfacial energy of neopentylglycol
Y Ocak1, S Akbulut, K Keşlioğlu
1Faculty of Arts and Sciences, Department of Physics, Erciyes University, 38039 Kayseri, Turkey.
Abstract:
The grain boundary groove shapes for equilibrated solid neopentylglycol (2,2-dimethyl-1,3-propanediol) (NPG) with its melt were directly observed by using a horizontal temperature gradient stage. From the observed grain boundary groove shapes, the Gibbs-Thomson coefficient (Gamma), solid-liquid interfacial energy (sigma(SL)), and grain boundary energy (sigma(gb)) of NPG have been determined to be (7.4+/-0.7)x10(-8) Km, (7.9+/-1.2)x10(-3) Jm(-2), and (15.4+/-2.5)x10(-3) Jm(-2), respectively. The ratio of thermal conductivity of equilibrated liquid phase to solid phase for the NPG has also been measured to be 1.07 at the melting temperature.
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