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Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology
Kyung-Jin Lee1, Won-Il Joo, Hyung-Kyun Rha
1Department of Neurosurgery, The Catholic University of Korea, Seoul, 150-713, South Korea.
Background:
The purpose of this study was to evaluate the radiologic characteristics and pathology related to the formation of peritumoral edema in meningiomas.
Methods:
Seventy-nine patients with meningioma were examined by MRI and cerebral angiography. The predictive factors possibly related to peritumoral edema, such as patient age, sex, tumor location, tumor size, peritumoral rim (CSF cleft), shape of tumor margin, signal intensity of tumor in T2WI, pial blood supply, and pathology, were evaluated. We defined the edema-tumor volume ratio as EI and used this index to evaluate peritumoral edema.
Results:
Male sex (P = .009), tumor size (P = .026), signal intensity of tumor in T2WI (P = .016), atypical and malignant tumor (P = .004), and pial blood supply (P = .001) correlated with peritumoral edema on univariate analyses. However, in multivariate analyses, pial blood supply was statistically significant as a factor for peritumoral edema in meningioma (P = .029). Male sex (P = .067, P < .1) and hyperintensity in T2WI (P = .075, P < .1) might have statistical probability in peritumoral edema.
Conclusions:
In our results, male sex, hyperintensity on T2WI, and pial blood supply were associated with peritumoral edema in meningioma that influence the clinical prognosis of patients.
Insights
Pial blood supply is a key factor in meningioma peritumoral edema. Male sex and T2WI hyperintensity also show potential links to this edema, impacting patient prognosis.
Area of Science:
- Neuro-oncology
- Radiology
- Pathology
Background:
- Meningiomas are primary tumors of the meninges.
- Peritumoral edema is a common complication of meningiomas.
- Understanding factors contributing to edema is crucial for patient management.
Purpose of the Study:
- To investigate radiologic and pathologic features associated with peritumoral edema in meningiomas.
- To identify predictive factors for edema formation.
- To evaluate the edema-tumor volume ratio (EI).
Main Methods:
- Seventy-nine meningioma patients underwent MRI and cerebral angiography.
- Evaluated factors included age, sex, tumor location, size, T2WI signal, and vascular supply.
- Edema-tumor index (EI) was used to quantify peritumoral edema.
Main Results:
- Univariate analysis showed correlation between edema and male sex, tumor size, T2WI hyperintensity, tumor grade, and pial blood supply.
- Multivariate analysis identified pial blood supply as a significant predictor of peritumoral edema.
- Male sex and T2WI hyperintensity showed potential statistical significance.
Conclusions:
- Pial blood supply is a significant factor associated with meningioma peritumoral edema.
- Male sex and T2WI hyperintensity may also be linked to edema.
- These factors influence the clinical prognosis of patients with meningioma.
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