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Related Concept Videos

Urologic Endoscopic Procedure: Cystoscopic Examination01:28

Urologic Endoscopic Procedure: Cystoscopic Examination

Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
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Related Experiment Video

Updated: Jul 7, 2026

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

Laparoscopy in ureteral engineering: a feasibility study.

Hervé Baumert1, Mehrak Hekmati, Irene Dunia

  • 1Department of Urology, Paris Saint Joseph Hospital Trust, Paris, France. baumertherve@yahoo.fr

European Urology
|February 12, 2008
PubMed
Summary

Laparoscopic implantation of bioengineered ureter substitutes in pigs demonstrated successful vascularization and urothelial differentiation. Carbon dioxide insufflation did not negatively impact tissue maturation, validating this minimally invasive approach for ureter regeneration.

Related Experiment Videos

Last Updated: Jul 7, 2026

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Minimally Invasive Surgery

Background:

  • Ureter reconstruction often requires open surgery.
  • Bioengineered ureter substitutes seeded with urothelial and smooth muscle cells show promise.
  • Minimally invasive laparoscopic techniques are desirable for ureter substitute implantation.

Purpose of the Study:

  • To evaluate the feasibility of laparoscopic implantation of bioengineered ureter substitutes.
  • To assess the biological impact of carbon dioxide insufflation on ureter substitute maturation.
  • To determine if laparoscopic omental maturation replicates results from open surgery.

Main Methods:

  • Full-thickness bladder tissue was harvested laparoscopically from pigs for cell culture.
  • Cells were used to seed a small intestinal submucosa (SIS) matrix.
  • Constructs were implanted laparoscopically into the omentum for maturation and analyzed histologically and ultrastructurally.

Main Results:

  • Laparoscopic implantation and omental maturation were successful in all animals.
  • Constructs exhibited vascularization and a well-differentiated urothelium with umbrella cells.
  • No fibrosis or inflammation was observed; electron microscopy confirmed terminal urothelial differentiation.

Conclusions:

  • Carbon dioxide insufflation does not adversely affect cell growth and differentiation in ureter substitutes.
  • The laparoscopic approach is validated for the omental maturation of bioengineered ureter substitutes.
  • This study supports the use of minimally invasive techniques for ureter regeneration.