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Updated: Jul 7, 2026

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
Published on: June 24, 2013
A new reconstruction approach for reflection mode diffraction tomography
1Dept. of Radiol., Chicago Univ., IL 60637, USA. anastasi@jedi.bsd.uchicago.edu
Abstract:
Reflection mode diffraction tomography (RM DT) is an inversion scheme used to reconstruct the acoustical refractive index distribution of a scattering object. In this work, we reveal the existence of statistically complementary information inherent in the backscattered data and propose reconstruction algorithms that exploit this information for achieving a bias-free reduction of image variance in RM DT images. Such a reduction of image variance can potentially enhance the detectability of subtle image features when the signal-to-noise ratio of the measured scattered data is low in RM DT. The proposed reconstruction algorithms are mathematically identical, but they propagate noise and numerical errors differently. We investigate theoretically, and validate numerically, the noise properties of images reconstructed using one of the reconstruction algorithms for several different multifrequency sources and uncorrelated data noise.
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