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Updated: Jul 7, 2026

Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth

Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth

Published on: February 9, 2012

Vibration safety limits for magnetic resonance elastography.

E C Ehman¹, P J Rossman, S A Kruse

¹Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

Physics in Medicine and Biology

|February 12, 2008

Summary

Magnetic resonance elastography (MRE) uses mechanical waves to assess tissue stiffness. This study found MRE vibration amplitudes are safe, falling below European Union occupational exposure limits, ensuring patient safety in human MRE studies.

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

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Published on: December 18, 2016

Area of Science:

Biomedical Engineering
Medical Imaging
Biomechanics

Background:

Magnetic resonance elastography (MRE) is a promising clinical tool for non-invasively measuring tissue stiffness in vivo.
Generating acoustic mechanical waves within tissues is crucial for MRE data acquisition.
Human MRE trials are increasing, necessitating an evaluation of vibrational exposure safety.

Purpose of the Study:

To audit vibration amplitudes used in Institutional Review Board (IRB)-approved human MRE studies.
To compare these amplitudes against established regulatory standards for vibrational exposure.
To assess the suitability of these standards for MRE applications.

Main Methods:

Examined MRE displacement data from 29 human MRE examinations across various organs (liver, brain, kidney, breast, skeletal muscle).
Adapted European Union (EU) directive 2002/44/EC occupational vibration limits for MRE exposure parameters (time, frequency).
Converted EU acceleration limits to maximum displacement values for comparison with in vivo measurements.

Main Results:

Measured in vivo vibrational displacements in human MRE studies were consistently below the calculated EU whole-body vibration limit.
The EU guidelines provide a quantifiable and conservative benchmark for vibrational exposure in MRE.
The findings support the safety of current MRE protocols in human subjects.

Conclusions:

Vibrational amplitudes employed in human MRE are well within the safe limits defined by EU occupational exposure directives.
EU vibration guidelines offer a practical and acceptable framework for IRB approval of MRE vibrational parameters.
This study validates the safety of MRE for clinical use and provides a standard for future human studies.