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Updated: Jul 7, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
"Treasure your exceptions": recent advances in molecular genetics of glomerular disease
Andrzej Ciechanowicz1, Andrzej Brodkiewicz, Agnieszka Bińczak-Kuleta
1Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Powstańcow Wielkopolskich 72, 70-111 Szczecin, Poland. aciech@sci.pam.szczecin.pl
Abstract:
The glomerular filtration barrier consists of endothelial cells, the glomerular basement membrane, and podocytes. The membrane is a highly crosslinked macromolecular meshwork composed of specific extracellular matrix proteins. The adjacent foot processes of podocytes are bridged along their basolateral surfaces by a slit diaphragm (a porous filter structure of nephrin molecules). Recent discoveries of mutations in the range of genes encoding proteins involved in the structure or function of the glomerular filtration barrier have provided new insights into mechanisms of glomerular diseases. In this review, we summarize recent progress in the elucidation of the genetic basis of some glomerulopathies in humans.
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