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Updated: Jul 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Systematic prenatal screening for psychosocial risks
Patricia A Harrison1, Abbey C Sidebottom
1Research and Program Development, Minneapolis Department of Health and Family Support, Minneapolis, MN 55415-1384, USA. pat.harrison@ci.minneapolis.mn.us
Insights
The Prenatal Risk Overview (PRO) tool identified significant psychosocial risks, including housing instability and lack of social support, in nearly half of prenatal patients. Early screening is crucial for addressing these factors to improve birth outcomes.
Area of Science:
- Maternal and Child Health
- Public Health
- Psychosocial Epidemiology
Background:
- Prenatal psychosocial risk factors significantly impact birth outcomes.
- Effective screening tools are needed to identify at-risk populations.
- Community health centers play a vital role in prenatal care delivery.
Purpose of the Study:
- To describe the development and implementation of the Prenatal Risk Overview (PRO).
- To examine the prevalence, co-occurrence, and inter-correlations of psychosocial risks in a prenatal population.
- To establish a baseline for assessing the impact of risk identification on birth outcomes.
Main Methods:
- Development and implementation of the PRO tool across four community health centers.
- Screening of 1,386 prenatal patients between November 2005 and April 2007.
- Analysis of demographic data and prevalence of 13 psychosocial risk factors.
Main Results:
- High prevalence of housing instability (48%), food insecurity (32%), and lack of social support (75%).
- Significant rates of depression (18%) and substance use (23% cigarette, 23% alcohol, 25% drug use) were observed.
- Low but present rates of intimate partner violence (7%) and other abuse (9%) were reported.
Conclusions:
- The PRO tool effectively identifies a high burden of psychosocial risks in diverse prenatal populations.
- Systematic assessment of these risks is essential for targeted interventions.
- Quantifying risks is a critical step towards reducing adverse infant outcomes like mortality and preterm birth.
Abstract:
The Prenatal Risk Overview (PRO) was designed to screen for 13 psychosocial risk factors associated with poor birth outcomes. This study describes the development and implementation of the PRO in 4 community health centers. The study also examines the prevalence, co-occurrence, and inter-correlations of psychosocial risks in their prenatal populations. The study sample included 1,386 prenatal patients screened between November 2005 and April 2007; 95% were women of color; 77% were not married. The PRO classified 48% at moderate or high risk for housing instability; 32% for food insecurity; 75% for lack of social support; 7% for intimate partner violence; 9% for other physical/sexual abuse; 18% for depression; 23% for cigarette use, 23% for alcohol use, and 25% for drug use. Systematically assessing and quantifying psychosocial risks are essential activities for evaluating the extent to which appropriate and timely responses to identified risks reduce infant mortality, preterm births, and low birth weights.
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