Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mouse embryo fibroblast (MEF) feeder cell preparation.

Current protocols in molecular biology·2008

Same author

Mouse embryonic stem (ES) cell culture.

Current protocols in molecular biology·2008

Same author

Chimeric mouse production by microinjection.

Current protocols in molecular biology·2008

Same author

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

Cell·2001

Same author

Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.

Molecular and cellular biology·2001

Same author

Comparison of two murine models of familial hypertrophic cardiomyopathy.

Circulation research·2001

Search research articles

Related Experiment Video

Updated: Oct 24, 2025

Isolation and Culture of Embryonic Mouse Neural Stem Cells

Isolation and Culture of Embryonic Mouse Neural Stem Cells

Published on: November 11, 2018

Mouse embryonic stem (ES) cell isolation.

¹Harvard Medical School, Boston, Massachusetts, USA.

Current Protocols in Molecular Biology

|February 12, 2008

Summary

This summary is machine-generated.

This study details the isolation of mouse embryonic (ES) stem cells, crucial for genetic engineering. These stem cells enable the creation of mouse mutants and the analysis of their phenotypes.

More Related Videos

Isolation and Derivation of Mouse Embryonic Germinal Cells

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM

Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM

Published on: June 27, 2008

Related Experiment Videos

Last Updated: Oct 24, 2025

Isolation and Culture of Embryonic Mouse Neural Stem Cells

Isolation and Culture of Embryonic Mouse Neural Stem Cells

Published on: November 11, 2018

Isolation and Derivation of Mouse Embryonic Germinal Cells

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM

Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM

Published on: June 27, 2008

Area of Science:

Developmental Biology
Stem Cell Biology
Genetics

Background:

Embryonic stem (ES) cells are foundational in genetic manipulation of mice.
Previous technological advancements provide a basis for current methods.

Purpose of the Study:

To describe the fundamental technique for isolating mouse embryonic stem cells.
To highlight the utility of ES cells in genetic research.

Main Methods:

Isolation of mouse embryonic stem cells.
Utilizing established technologies from prior research.

Main Results:

Successfully isolated mouse embryonic stem cells.
Demonstrated the applicability of ES cells for generating mouse mutants.
Showcased the use of ES cells in analyzing mutant phenotypes.

Conclusions:

Mouse embryonic stem cell isolation is a key technique for genetic research.
ES cells are versatile tools for creating and studying mouse models of genetic diseases.