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Onychomycosis caused by Chaetomium globosum Kunze
J Naidu1, S M Singh, M Pouranik
1Department of Biological Sciences, Rani Durgavati University, Jabalpur, India.
Mycopathologia
|January 1, 1991
Summary
This study details a rare case of fingernail onychomycosis caused by Chaetomium globosum. Oxiconazole demonstrated the highest in vitro effectiveness against this fungal nail infection.
Area of Science:
- Medical Mycology
- Dermatology
- Infectious Diseases
Background:
- Onychomycosis, a common nail fungal infection, can be caused by various fungi.
- Chaetomium globosum is an opportunistic mold rarely implicated in human infections, particularly onychomycosis.
Observation:
- A patient presented with fingernail lesions on the left hand.
- Direct microscopy revealed light-brown hyphae with thick-walled cells in nail scrapings.
- Histopathology confirmed the presence of thick, aggregated hyphal elements within the nail plate.
Findings:
- Chaetomium globosum was identified as the causative agent of onychomycosis.
- In vitro susceptibility testing showed oxiconazole to be the most effective antifungal agent.
- The minimum inhibitory concentration (MIC) of oxiconazole against the isolate was 0.3 µg/mL.
Implications:
- This case highlights Chaetomium globosum as a potential pathogen in onychomycosis.
- Oxiconazole shows promise as an effective treatment option for this specific fungal nail infection.
- Further research into the clinical significance and treatment of Chaetomium-induced onychomycosis is warranted.