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Updated: Jul 7, 2026

Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging
Published on: January 17, 2025
Inclusions in aged mitochondria
1Agricultural Research Council, Meat Research Institute, Langford, Bristol, BS18 7DY, UK.
Abstract:
The formation of paracrystalline inclusions in mitochondria following postmortem aging in situ is further investigated. Inclusions are found to localize either in the mitochondrial intracristal space or between the inner and outer membrane. The greater majority of the inclusions are of the intracristal type. pH is not an important factor in the formation of the inclusions, since lowering the pH of the mitochondrial suspensions does not increase the number of mitochondria with inclusions. It is concluded that changes associated with aging during the prolonged preservation of the mitochondria both in situ and in in vitro experiments are probably the principal cause for the formation of the mitochondrial inclusions.
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