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Thyroid dysfunction in patients with Down syndrome.

Ming-Hua Chen1, Shyh-Jye Chen, Li-Ying Su

  • 1Department of Pediatrics, Taipei City Hospital Yangming Branch, Taiwan. dag79@tpech.gov.tw

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
|February 13, 2008
PubMed
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Thyroid dysfunction is prevalent in Down syndrome (DS) individuals in Taiwan, with 18% affected. Early thyroid function tests and treatment are crucial for managing DS patients and improving their development.

Area of Science:

  • Endocrinology
  • Genetics
  • Pediatrics

Background:

  • Down syndrome (DS) is frequently associated with thyroid disorders.
  • Previous literature highlights a strong connection between DS and thyroid dysfunction.
  • This study investigates the prevalence and patterns of thyroid dysfunction specifically in Taiwanese DS patients.

Purpose of the Study:

  • To determine the prevalence of thyroid dysfunction in Down syndrome individuals in Taiwan.
  • To analyze the specific patterns of thyroid dysfunction observed in this population.
  • To provide data supporting the need for regular thyroid monitoring in DS patients.

Main Methods:

  • Recruited 50 Down syndrome (DS) patients from a care facility in Taiwan.
  • Measured serum levels of T3, T4, free T4, TSH, thyroid peroxidase antibody (anti-TPO), and anti-TSH receptor antibody.

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  • Compared findings with a control group of 212 healthy adults.

    • Main Results:

    • 18% (9/50) of DS patients exhibited thyroid dysfunction.
    • Subclinical hypothyroidism was observed in 16% (8/50) and hyperthyroidism in 2% (1/50).
    • Elevated TSH levels were significantly more common in the DS group compared to controls (p = 0.008).

    Conclusions:

    • Thyroid dysfunction is a common comorbidity in Down syndrome (DS) patients.
    • Routine thyroid function screening is recommended for all individuals with DS.
    • Timely intervention for thyroid abnormalities can aid in preventing intellectual decline and enhancing overall development in DS patients.