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Intra-arterial chemotherapy of advanced pancreatic cancer: a single center experience
Carlo Milandri1, Filippo Calzolari, Alessandro Passardi
1Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy. res.onco@ausl.fo.it
Background/Aims:
The main aim of the present work was to determine response rates and time to progression in patients with locally advanced or metastatic pancreatic cancer treated with intra-arterial chemotherapy.
Methodology:
Nineteen chemotherapy-naive patients with measurable lesions were treated with intra-arterial 5-fluorouracil 1000 mg/m2, leucovorin 100 mg/m2, carboplatin 300 mg/m2 and epirubicin 60 mg/m2 (FLEC regimen) every 21 days. Prophylactic granulocyte colony-stimulating factors were administered on days 4-10 of each cycle.
Results:
There were 16 patients evaluable for response, of whom 4 (25%) had a partial response, 7 (44%) showed stable disease, and 5 (31%) progressed. Marker response rate was 43%. Median time to progression was 4 months and median overall survival was 6 months. One-year overall survival was 16%. No grade 4 toxicity or severe complications relating to the angiographic procedure were observed.
Conclusions:
Our results show that intra-arterial FLEC is well tolerated and active against advanced pancreatic cancer.
