Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Malnutrition in head and neck cancer patients: Impacts and indications of a prophylactic percutaneous endoscopic gastrostomy.

European annals of otorhinolaryngology, head and neck diseases·2019

Same author

Transanal endolaparoscopic circumferential mucosectomy for symptomatic benign rectal stenosis - a video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2017

Same author

A rare case of a pancreatic mass due to accessory spleen; when EUS-FNA is not enough.

Endoscopy·2011

Same author

[Dysphagia and recurrent esophageal stenosis associated with intramural pseudodiverticulosis of the esophagus. A case report].

Revue medicale de Bruxelles·2011

Same author

[Coronary artery aneurysm associated with fistula: two anatomically similar cases with different clinical presentation].

Revue medicale de Bruxelles·2010

Same author

Black pigments in the liver related to gold and titanium deposits. A report of four cases.

Liver international : official journal of the International Association for the Study of the Liver·2007

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

[Autoimmune hepatitis and CREST syndrome].

N Ngo Mandag¹, M Van Gossum, F Rickaert

¹Service de Gastroentérologie, C.H.U. Saint-Pierre, Site César De Paepe.

Revue Medicale De Bruxelles

|February 13, 2008

Summary

This case report highlights a rare instance of autoimmune hepatitis in a 59-year-old woman with a history of CREST syndrome. The study emphasizes the uncommon co-occurrence of these two distinct autoimmune conditions.

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Related Experiment Videos

Last Updated: Jul 7, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Area of Science:

Hepatology
Immunology
Rheumatology

Background:

Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune-mediated liver cell injury.
CREST syndrome (Calcinosis, Raynaud's phenomenon, esophageal dysmotility, Sclerodactyly, and Telangiectasia) is a rare variant of systemic sclerosis.

Observation:

A 59-year-old woman presented with progressive jaundice, a key symptom of liver dysfunction.
Her medical history revealed a prior diagnosis of CREST syndrome.

Findings:

The patient was diagnosed with autoimmune hepatitis.
This case is notable for the rare co-occurrence of autoimmune hepatitis and CREST syndrome in the same individual.

Implications:

This report underscores the importance of considering autoimmune liver disease in patients with systemic autoimmune conditions like CREST syndrome.
Further research may elucidate shared etiological factors or pathogenic mechanisms between AIH and CREST syndrome.