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Updated: Jul 7, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Targeted therapy in renal cell carcinoma
Jean-Jacques Patard1, Damien Pouessel, Karim Bensalah
1Department of Urology, Rennes University Hospital, CHU Pontchaillou, rue Henri le Guillou, 35033 Rennes, France. jean-jacques.patard@univ-rennes1.fr
World Journal of Urology
|February 13, 2008
Summary
New anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) improve survival for metastatic renal cell carcinoma patients. Four effective therapies are now available for first and second-line treatment.
Area of Science:
- Oncology
- Medical Research
Background:
- Metastatic renal cell carcinoma (mRCC) treatment has advanced with targeted therapies.
- Understanding molecular pathways in clear cell carcinomas is key to developing new treatments.
Purpose of the Study:
- To provide an update on anti-angiogenic drugs for metastatic renal cell carcinoma.
- To summarize current therapeutic options and their efficacy.
Main Methods:
- Review of clinical trial data for targeted therapies in mRCC.
- Analysis of drugs targeting vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR).
Main Results:
- Tyrosine kinase inhibitors targeting VEGF receptors (Sunitinib, Sorafenib) improve progression-free survival.
- Temsirolimus (mTOR inhibitor) improves overall survival in poor-risk patients.
- Bevacizumab (anti-VEGF antibody) combined with interferon shows improved response rates and progression-free survival.
Conclusions:
- Four major anti-angiogenic drugs/regimens are now available for first and second-line mRCC therapy.
- Further research is needed to optimize drug combinations and evaluate adjuvant therapy effectiveness.
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