Related Experiment Video
Updated: Jul 7, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
Successful steroid treatment in a patient with membranoproliferative glomerulonephritis associated with hepatitis C
Toru Sanai1, Izumi Watanabe, Tadashi Hirano
1Division of Nephrology, National Kyushu Medical Center, Fukuoka, Japan. sunny@cc.saga-u.ac.jp
Abstract:
Thirteen years ago, a 65-year-old woman was diagnosed to have chronic active hepatitis with hepatitis C virus. After starting interferon alpha administration, she noticed edema and hypoalbuminemia. Renal biopsy revealed mesangial proliferation with focal endocapillary proliferation, and double contour of the glomerular basement membrane due to mesangial interposition. Interferon alpha was discontinued, and proteinuria and edema gradually decreased. She was re-admitted due to a relapse of proteinuria 8 years later. Biopsy revealed moderate mesangial and endcapillary proliferation presenting a lobular pattern, in addition to the presence of hyaline thrombi. Granular staining of immunoglobulin M and of C3 in capillary walls were detected. Since cryoglobulinemia was positive, a final diagnosis of cryoglobulinemic membranoproliferative glomerulonephritis was made. Prednisolone was started with an initial dose of 20 mg/day. Proteinuria and hypoalbuminemia improved, and prednisolone was tapered to 5 mg/day 9 months after the 2nd renal biopsy. The hepatitis C virus-RNA titer fluctuated.
Related Concept Videos
Hepatitis
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Nephrotic Syndrome III : Nursing Management
Inhibitors of Viral Protein Synthesis