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Prediabetes: a must to recognise disease state
W Shehab Eldin1, M Emara, A Shoker
1Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada.
Insights
Prediabetes mellitus (PDM) is a curable disease, not just a precursor to type 2 diabetes. Early diagnosis and adherence to treatment guidelines are crucial for managing this condition.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Prediabetes mellitus (PDM) signifies abnormal glucose homeostasis, characterized by insulin deficiency or resistance.
- PDM precedes overt type 2 diabetes and is linked to increased mortality and morbidity, meeting disease criteria.
Purpose of the Study:
- To elevate awareness of PDM as a distinct disease state requiring early intervention.
- To advocate for PDM to be recognized as a disease rather than a 'pre' stage of diabetes.
Main Methods:
- Reviewing diagnostic guidelines for PDM.
- Discussing the prevalence and associated hazards of PDM.
- Elaborating on current PDM treatment guidelines.
Main Results:
- Sufficient evidence confirms that PDM is a curable disease state.
- Current treatment protocols for PDM are effective.
Conclusions:
- Adherence to established PDM treatment recommendations is essential.
- Exploration of additional pharmacological agents for PDM management is warranted.
Unlabelled:
Prediabetes mellitus (PDM) is defined as a state of abnormal glucose homeostasis in which deficiency or resistance to insulin is the hallmark. PDM precedes the development of overt type 2 DM. It is associated with increased mortality and morbidity and thus fits well with the criteria of a disease condition. Framing PDM as a disease and not a risk or a 'pre' stage for diabetes is needed to facilitate early management.
Aim:
This review aims therefore to increase awareness of PDM as a disease state.
Methods:
To do so, we shall preview guidelines for its diagnosis. Its prevalence and hazards will be then discussed. Finally, we shall elaborate on the current treatment guidelines.
Result:
Enough evidence support the notion that PDM is a curable disease state.
Conclusions:
The current recommendations for the treatment of PDM should be adhered. In addition, there is a room for the use of other pharmacological agents.
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