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Determining the relationship between metabolic syndrome score and angiographic severity of coronary artery disease
1Hacettepe University Faculty of Medicine, Department of Cardiology, Ankara, Turkey. byavuzmd@gmail.com
Insights
Metabolic syndrome (MS) severity correlates with increased coronary artery disease (CAD) angiographic severity. Diabetes mellitus in males and hypertension in females were key factors influencing Gensini scores in this study.
Area of Science:
- Cardiology
- Metabolic Disorders
Background:
- Cardiovascular disease (CVD) is a major global health burden.
- Metabolic syndrome (MS) is a known risk factor for coronary artery disease (CAD).
- The precise impact of MS on the angiographic severity of CAD requires further elucidation.
Purpose of the Study:
- To investigate the relationship between metabolic syndrome (MS) and the angiographic severity of coronary artery disease (CAD).
- To quantify this association using the Gensini score.
Main Methods:
- 1003 patients undergoing elective coronary angiography were analyzed.
- Metabolic syndrome (MS) was assessed using the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria, yielding an MS score.
- Coronary angiograms were evaluated to determine the Gensini score for each patient.
Main Results:
- The study included 634 males (63%) and 369 females (37%), with a mean age of 59 years.
- Metabolic syndrome (MS) was identified in 246 patients (25%).
- A significant positive correlation (r = 0.402, p < 0.001) was observed between the MS score and the Gensini score, indicating increased CAD severity with higher MS severity.
Conclusions:
- Increasing severity of metabolic syndrome (MS) is associated with greater angiographic severity of coronary artery disease (CAD).
- Diabetes mellitus was the primary determinant of Gensini score in males.
- Hypertension was the primary determinant of Gensini score in females.
Background:
Cardiovascular disease is leading cause of mortality and morbidity in developed and developing countries. Metabolic syndrome (MS) is a risk factor for coronary artery disease (CAD). The effect of MS on angiographic severity of CAD is not well defined. The aim of this study was to examine the effect of MS on angiographic severity of CAD by using Gensini score.
Methods:
The total number of 1003 patients who underwent elective coronary angiography in catheter laboratory were included in the study. MS score based on National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria which ranged between zero and five were calculated for each subject. Gensini scores were determined by examining coronary angiograms of the patients.
Results:
The study population consisted of 634 (63%) male, and 369 (37%) female subjects. The mean age was 59 +/- 11. MS based on NCEP ATP III was present in 246 (25%) patients. CAD was present in 691 patients (69%). The median of Gensini score was five (0-192) in the total sample, 18 (1-192) in the patients with CAD and 25 (0-192) in the patients with MS. A positive correlation was found between MS score and Gensini score (r = 0.402, p < 0.001).
Conclusions:
In this study, it was determined that as the severity of MS increases, the angiographic severity of CAD increases as well. Besides, the most important factor on Gensini score was diabetes mellitus in male and hypertension in female subjects.
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