Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Overview of the Vascular System

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Varicose Veins I: Introduction

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Position paper on a simplified histopathological classification of basal cell carcinoma: results of the European Consensus Project.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Same author

Skin adnexal tumours in a tertiary dermatopathology service.

The British journal of dermatology·2021

Same author

A rare mimic of basal cell carcinoma.

Clinical and experimental dermatology·2021

Same author

Patient characteristics in tardive COVID-19 pseudoperniosis: a case series of 16 patients.

Clinical and experimental dermatology·2021

Same author

Progressive atrophic indurated plaques in a 16-year-old boy.

Clinical and experimental dermatology·2021

Same author

Chronic lymphocytic leukaemia-associated insect bite-like reaction responding to ibrutinib, an immunomodulatory Bruton tyrosine kinase inhibitor.

Clinical and experimental dermatology·2021

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

A Patient-Derived Xenograft Model for Venous Malformation

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Cutaneous vascular tumours: an update.

S G N Goh¹, E Calonje

¹St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

|February 13, 2008

Summary

This review examines evolving vascular tumor classifications, focusing on intermediate malignancy types like haemangioendotheliomas. It details recently identified vascular tumors and updated congenital haemangioma classifications.

Area of Science:

Vascular Oncology
Pathology
Dermatology

Background:

Vascular tumor classification requires regular updates due to new discoveries.
Existing classifications may not encompass all recently identified vascular lesions.

Purpose of the Study:

To review and summarize changes in vascular nomenclature.
To describe recently characterized vascular tumors and updated classifications.

Main Methods:

Literature review of vascular tumor classifications and newly described entities.
Analysis of recent advancements in understanding vascular tumors.

Main Results:

Evaluation of intermediate malignancy vascular tumors including haemangioendotheliomas, Kaposi's sarcoma, and giant cell angioblastoma.

More Related Videos

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Jul 7, 2026

A Patient-Derived Xenograft Model for Venous Malformation

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

Published on: April 12, 2024

Description of newly identified tumors: composite haemangioendothelioma, acquired elastotic haemangioma, symplastic haemangioma, cutaneous epithelioid angiomatous nodule, and cutaneovisceral angiomatosis with thrombocytopenia.

Review of new clinical classifications for congenital haemangiomas and radiation-induced atypical vascular lesions.

Conclusions:

The field of vascular tumors is dynamic, with ongoing refinement of classification systems.
Accurate nomenclature and classification are crucial for diagnosis and treatment of vascular tumors.