Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

91.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.0K
Spermatogenesis01:22

Spermatogenesis

8.3K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.3K
Sperm Transport01:15

Sperm Transport

5.5K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
5.5K
Vagina01:26

Vagina

62.7K
The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
62.7K
Uterine Tubes01:16

Uterine Tubes

4.1K
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
4.1K
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

53
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
53

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1.

Current biology : CB·2026
Same author

High-Fidelity Long-term Whole-embryo Lineage and Fate Reconstruction by Iterative Tracking with Error Correction.

bioRxiv : the preprint server for biology·2026
Same author

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis.

Science (New York, N.Y.)·2026
Same author

The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement.

Current biology : CB·2025
Same author

Collective Cell Migration Strategies: Patterning, Motility, and Directionality of the Posterior Lateral Line Primordium in Zebrafish.

Cold Spring Harbor perspectives in biology·2025
Same author

Widespread temporal niche partitioning in an adaptive radiation of cichlid fishes.

Nature ecology & evolution·2025
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
Same journal

Structural basis for host membrane binding and remodeling by invading malaria parasites.

Cell·2026
Same journal

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026
Same journal

Arc mediates intercellular tau transmission via extracellular vesicles.

Cell·2026
Same journal

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Isolation of Lymphocytes from Mouse Genital Tract Mucosa
04:46

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Published on: September 3, 2012

14.1K

Clearing the path for germ cells.

Holger Knaut1, Alexander F Schier

  • 1Developmental Genetics Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

Cell
|February 13, 2008
PubMed
Summary
This summary is machine-generated.

CXCR7, a second receptor for SDF-1a, is crucial for zebrafish germ cell migration. It functions by sequestering SDF-1a, not signaling, emphasizing ligand clearance in cell guidance.

More Related Videos

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

8.4K
An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

1.3K

Related Experiment Videos

Last Updated: May 1, 2026

Isolation of Lymphocytes from Mouse Genital Tract Mucosa
04:46

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Published on: September 3, 2012

14.1K
Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

8.4K
An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

1.3K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • Germ cell migration is essential for reproduction and development.
  • Chemokines, like SDF-1a, and their receptors guide cell movement through signaling pathways.
  • Zebrafish are a key model organism for studying developmental processes.

Discussion:

  • The study identifies CXCR7 as a novel receptor for SDF-1a in zebrafish germ cell migration.
  • CXCR7's role is distinct from CXCR4b; it acts as a scavenger, not a signaling molecule.
  • This finding suggests a dual-receptor mechanism for SDF-1a, involving both signaling and sequestration.

Key Insights:

  • CXCR7 is essential for guided germ cell migration in zebrafish.
  • CXCR7 functions by binding and sequestering the chemokine SDF-1a.
  • Ligand sequestration by CXCR7 is critical for effective cell migration, highlighting the importance of chemokine clearance.

Outlook:

  • Further research into CXCR7's mechanism could reveal new therapeutic targets for developmental disorders.
  • Understanding ligand clearance pathways may offer insights into other cell migration processes.
  • Investigating CXCR7 in other species could broaden our understanding of conserved migration mechanisms.