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Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

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Related Experiment Video

Updated: Jul 7, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

CDK inhibitors: cell cycle regulators and beyond.

Arnaud Besson1, Steven F Dowdy, James M Roberts

  • 1Université de Toulouse - LBCMCP and CNRS - UMR5088, Toulouse, France.

Developmental Cell
|February 13, 2008
PubMed
Summary
This summary is machine-generated.

The Cip/Kip family proteins, including p21Cip1, p27Kip1, and p57Kip2, regulate cell cycle and have broader roles in cell functions. Phosphorylation networks fine-tune their activities, crucial for tissue homeostasis and tumor suppression.

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: May 14, 2016

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The Cip/Kip family proteins (p21Cip1, p27Kip1, p57Kip2) were initially identified as cell cycle inhibitors.
  • These proteins mediate growth inhibitory signals from upstream pathways.
  • Emerging evidence highlights their diverse roles beyond cell cycle control.

Purpose of the Study:

  • To explore the multifaceted functions of Cip/Kip proteins.
  • To understand the regulatory mechanisms governing Cip/Kip protein activity.
  • To elucidate the significance of Cip/Kip proteins in cellular processes and homeostasis.

Main Methods:

  • Review of existing literature on Cip/Kip protein family.
  • Analysis of signaling pathways involving Cip/Kip proteins.
  • Investigation of post-translational modifications, particularly phosphorylation.

Main Results:

  • Cip/Kip proteins regulate not only the cell cycle but also apoptosis, transcription, cell fate, migration, and cytoskeleton dynamics.
  • A complex phosphorylation network modulates Cip/Kip protein localization, interactions, and stability.
  • These regulatory mechanisms are vital for maintaining cell and tissue homeostasis.

Conclusions:

  • Cip/Kip proteins are key regulators with diverse cellular functions.
  • Phosphorylation is a critical modulator of Cip/Kip protein activity and cellular roles.
  • These proteins are essential for embryonic development and tumor suppression, highlighting their importance in health and disease.