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Published on: February 28, 2012
Libman-Sacks endocarditis and cerebral embolization in antiphospholipid syndrome
Mai Tone Lønnebakken1, Eva Gerdts
1Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway. mai.tone.lonnebakken@helse-bergen.no
Summary
Antiphospholipid syndrome (APS) patients with Libman-Sacks endocarditis require warfarin therapy. This prevents dangerous blood clots in the heart valves, reducing stroke risk.
Area of Science:
- Cardiology
- Rheumatology
- Neurology
Background:
- Antiphospholipid syndrome (APS) is linked to a high incidence of valvular heart disease.
- Valvular heart disease in APS increases the risk of thrombo-embolic events, especially cerebrovascular events.
Observation:
- A patient presented with cerebral infarction, prior deep-vein thrombosis, and miscarriages.
- The patient tested positive for lupus anticoagulant and anticardiolipin antibodies.
- Echocardiography showed mitral valve thickening and verrucous vegetations, indicative of Libman-Sacks endocarditis.
Findings:
- Libman-Sacks endocarditis is frequently associated with antiphospholipid syndrome.
- The combination of Libman-Sacks endocarditis and antiphospholipid antibodies signifies a high risk of valvular thrombus formation.
- Subsequent embolization from valvular thrombi poses a significant threat.
Implications:
- Anticoagulation therapy with warfarin is indicated for patients with concurrent Libman-Sacks endocarditis and antiphospholipid antibodies.
- Warfarin treatment is crucial for mitigating the risk of valvular thrombus and embolization.
- This management strategy aims to prevent severe outcomes like stroke in affected patients.
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