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Leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis. 1957
1Her Majesty's Stationary Office, London, UK.
Abstract:
Reported here is a seminal study of leukaemia among patients who had been treated with x-rays for ankylosing spondylitis. The findings were first published in a Medical Research Council (MRC) report in 1957. The report is now published in a scientific journal for the first time, 50 years after it first appeared.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
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