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[Changes in morning platelet aggregation in patients with peripheral obliterating arteriopathy after evening
A Craveri1, L Colombo, M Cristina
1Istituto di Scienze Biomediche, Università degli Studi di Milano, Ospedale S. Paolo.
Insights
Morning platelet aggregation, a factor in atherosclerosis, is reduced by evening administration of the anti-aggregant picotamide. This study investigated its effect on platelet function in patients with arterial disease.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Pharmacology
Background:
- Platelets play a crucial role in the development of atherosclerosis.
- A known morning surge in platelet aggregation occurs between 6 and 9 a.m.
Purpose of the Study:
- To evaluate the effect of evening administration of picotamide on platelet aggregation in patients with chronic occlusive arterial disease.
- To determine if picotamide can suppress the morning increase in platelet aggregation.
Main Methods:
- The study involved 10 patients with chronic occlusive arterial disease.
- Platelet aggregation was measured using the impedancemetric method in whole blood.
- Measurements were taken before and after evening administration of 300 mg picotamide.
Main Results:
- The study confirmed an increase in platelet aggregation between 6 a.m. and 9 a.m.
- Evening administration of picotamide effectively suppressed this morning increase in platelet aggregation.
Conclusions:
- The anti-aggregant picotamide can mitigate the morning surge in platelet aggregation.
- This finding suggests a potential therapeutic strategy for managing atherosclerosis progression related to morning thrombotic events.
Abstract:
Platelets are involved in the progressive pathogenesis of atherosclerosis. It has been shown that there is usually an increase in platelet aggregation between 6 and 9 a.m.; in the present study. in 10 patients suffering from chronic occlusive arterial disease, the impedancemetric method was used to evaluate, in whole blood, platelet aggregation induced by ADP and collagen the day prior to and the day following the evening administration of 300 mg picotamide. Analysis of the data obtained shows, in accordance with the findings of other authors, in increase of platelet aggregation from 6 a.m. to 9 a.m. This increase is suppressed by the evening administration of the anti-aggregant.