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Published on: September 15, 2017
[Thymic carcinoid tumor with Cushing syndrome]
Sanae Yamauchi1, Y Yamada, T Tsushima
1Department of Thoracic and Cardiovascular Surgery, Hirosaki University School of Medicine, Hirosaki, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|February 14, 2008
Summary
A rare thymic carcinoid tumor produced ectopic adrenocorticotropic hormone (ACTH), causing Cushing's syndrome. Surgical removal of the tumor resolved the condition, highlighting the importance of perioperative cortisol control.
Area of Science:
- Endocrinology
- Oncology
- Thoracic Surgery
Background:
- Ectopic adrenocorticotropic hormone (ACTH) syndrome can be caused by neuroendocrine tumors.
- Thymic carcinoid tumors are rare and can present with hormonal syndromes.
Observation:
- A 71-year-old male presented with fatigue and polyposia due to Cushing's syndrome.
- Diagnostic imaging revealed an anterior mediastinal mass, confirmed as a thymic carcinoid tumor.
- Elevated serum ACTH and cortisol levels, unresponsive to dexamethasone suppression, indicated ectopic hormone production.
Findings:
- Histological examination confirmed a typical carcinoid tumor with positive ACTH immunostaining.
- Complete surgical excision of the thymus and tumor led to rapid normalization of ACTH and cortisol levels.
- Postoperative improvement in clinical symptoms was observed.
Implications:
- This case underscores the significance of recognizing thymic carcinoid tumors as a cause of ectopic ACTH syndrome.
- Effective perioperative management of cortisol levels is crucial for preventing complications.
- Surgical resection offers a curative option for ectopic ACTH-producing thymic carcinoid tumors.
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