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Updated: Jul 7, 2026

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
Published on: May 20, 2012
[Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma]
Biao Wang1, Kai-hua Lu, Ya-nan Zhao
1Department of Plastic Surgery, Second Affiliated Hospital, Kunming Medical College, Kunming 650101, China.
Objective:
To investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma.
Methods:
Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin.
Results:
The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them (P > 0.05).
Conclusion:
Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.
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