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Related Concept Videos

Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
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Related Experiment Video

Updated: Jul 7, 2026

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
08:54

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements

Published on: May 1, 2017

[Omega-3 fatty acid preparations--a comparative study].

C Fierens1, J Corthout

  • 1Service de Contrôle des Médicaments.

Journal De Pharmacie De Belgique
|February 14, 2008
PubMed
Summary

Most fish oil supplements contain omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, 7 of 15 supplements failed quality tests, unlike the single medicine evaluated.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Analytical Chemistry

Background:

  • Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial components of fish oil supplements.
  • These fatty acids are available in various forms, including triglycerides, ethyl esters, and free fatty acids, impacting their bioavailability and stability.
  • Quality control of dietary supplements is essential to ensure product safety and efficacy, aligning with established pharmacopoeial standards.

Purpose of the Study:

  • To evaluate the quality of omega-3 fatty acid-containing food supplements and one medicinal product.
  • To assess compliance with European Pharmacopoeia standards for key quality indicators.
  • To identify potential deviations in peroxide value and fatty acid content among the evaluated products.

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Last Updated: Jul 7, 2026

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
08:54

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements

Published on: May 1, 2017

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
09:38

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans

Published on: November 29, 2013

Main Methods:

  • Analysis of 15 food supplements and 1 medicine formulated as soft capsules containing omega-3 fatty acids.
  • Application of European Pharmacopoeia methods for disintegration, anisidine value, peroxide value, and omega-3 fatty acid assay.
  • Quantification of major omega-3 fatty acids, specifically EPA (C20:5) and DHA (C22:6).

Main Results:

  • All products contained purified fish oil rich in EPA and DHA, presented as triglycerides, ethyl esters, or free fatty acids.
  • The medicinal product met all specified quality requirements.
  • Seven out of fifteen food supplements failed to meet one or more criteria, particularly concerning peroxide value and the content of specific fatty acids.

Conclusions:

  • While the medicinal product adhered to quality standards, a significant proportion of omega-3 food supplements exhibited quality deficiencies.
  • Deviations in peroxide value and fatty acid content suggest potential issues with product stability or formulation in some supplements.
  • Regulatory oversight and stringent quality control are vital for ensuring the safety and reliability of omega-3 fatty acid supplements.