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Related Experiment Video

Updated: Jul 7, 2026

$Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter$

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Epi-LASIK versus epi-LASEK.

Massimo Camellin¹, Daniel Wyler

¹Sekal Rovigo Microsurgery, Rovigo, Italy. cammas@tin.it

Journal of Refractive Surgery (Thorofare, N.J. : 1995)

|February 14, 2008

Summary

Adding 20% alcohol to the epithelial LASIK (epi-LASIK) procedure, creating epi-LASEK, improves flap creation and hinge quality without increasing pain or haze. This technique offers advantages for achieving intact hinges and perfect flaps in refractive surgery.

Area of Science:

Ophthalmology
Refractive Surgery
Corneal Surgery

Background:

Epithelial LASIK (epi-LASIK) is a refractive surgical technique.
Optimizing flap creation and postoperative outcomes is crucial in epi-LASIK.
The role of adjunct solutions in enhancing epi-LASIK procedures requires investigation.

Purpose of the Study:

To evaluate the benefits and drawbacks of incorporating a 20% alcohol solution into the epi-LASIK procedure.
To compare flap creation, postoperative haze, and pain levels between standard epi-LASIK and epi-LASIK with alcohol (epi-LASEK).

Main Methods:

A prospective study involving 45 patients comparing epi-LASIK with epi-LASEK.
A 20% alcohol solution was applied for 20 seconds before flap creation in the epi-LASEK group.

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Fellow eyes underwent either epi-LASIK or epi-LASEK, with refractive and topographic assessments preoperatively and postoperatively up to 360 days.

Main Results:

The epi-LASEK group demonstrated reduced postoperative astigmatism and corneal irregularities compared to the epi-LASIK group.
Alcohol application in epi-LASEK facilitated superior flap and hinge formation.
No significant increase in postoperative pain or haze was observed in the epi-LASEK group (P > .05).

Conclusions:

Alcohol facilitates improved flap creation and hinge quality during epi-LASIK.
Postoperative flap viability may not be critical for pain reduction or expedited recovery.
Incorporating alcohol into epi-LASIK (epi-LASEK) is advantageous for achieving optimal flap and hinge integrity.