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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

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Related Experiment Video

Updated: Jul 7, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

Nuclear factor kappa B and hepatitis viruses.

Yong-Song Guan1, Qing He, Ming-Quan Wang

  • 1West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. yongsongguan@yahoo.com

Expert Opinion on Therapeutic Targets
|February 14, 2008
PubMed
Summary
This summary is machine-generated.

Novel strategies targeting Nuclear factor kappa B (NF-kappaB) aim to combat hepatitis and liver cancer. NF-kappaB is crucial for immune responses and may act as an anti-cancer factor in liver carcinogenesis.

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Last Updated: Jul 7, 2026

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Published on: June 26, 2019

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Area of Science:

  • Hepatology
  • Immunology
  • Oncology

Background:

  • Hepatitis poses significant risks, including cirrhosis and liver cancer, with current treatments offering limited efficacy.
  • Viral hepatitis shares similar clinical signs, increasing mortality rates.
  • Nuclear factor kappa B (NF-kappaB) is vital for immune and inflammatory processes, requiring strict cellular regulation.

Purpose of the Study:

  • To investigate novel therapeutic strategies for hepatitis and associated liver cancer.
  • To focus on Nuclear factor kappa B (NF-kappaB) as a central target for treatment development.

Main Methods:

  • Comprehensive review of NF-kappaB regulatory mechanisms in hepatitis.
  • Analysis of NF-kappaB's role in immune and inflammatory pathways relevant to liver disease.

Main Results:

  • NF-kappaB is identified as a key player in the pathogenesis of hepatitis.
  • Evidence suggests NF-kappaB's potential role in combating inflammation-associated liver cancer.

Conclusions:

  • NF-kappaB is integral to hepatitis development.
  • NF-kappaB is hypothesized to function as an anti-cancer agent in inflammation-driven hepatocarcinogenesis.