Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Practical pathway for the management of depression in the workplace: a Canadian perspective.

Frontiers in psychiatry·2023

Same author

Best practice intervention for post-traumatic stress disorder among transit workers.

Work (Reading, Mass.)·2016

Same author

Facilitators and barriers to doing workplace mental health research: Case study of acute psychological trauma in a public transit system.

Work (Reading, Mass.)·2016

Same author

Help-seeking in transit workers exposed to acute psychological trauma: a qualitative analysis.

Work (Reading, Mass.)·2013

Same author

Factors associated with working status among workers assessed at a specialized worker's compensation board psychological trauma program.

American journal of industrial medicine·2011

Same author

The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: a randomized controlled trial in unmotivated smokers.

Addictive behaviors·2009

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Depression and the workplace: a progress report.

Ash Bender¹, Peter Farvolden

¹Work, Stress, and Health Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada. Ash_bender@camh.net

Current Psychiatry Reports

|February 14, 2008

Summary

This summary is machine-generated.

Depression is common in the workplace, impacting productivity and increasing costs. Addressing workplace depression requires overcoming stigma and implementing effective interventions for better employee well-being and organizational health.

More Related Videos

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Related Experiment Videos

Last Updated: Jul 7, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Area of Science:

Occupational Health
Clinical Psychology
Organizational Psychology

Background:

Depressive disorders are highly prevalent in the workplace.
Depression significantly impacts employee performance, productivity, absenteeism, and disability costs.
Clinical depression shares overlap with occupational health models like stress and burnout.

Purpose of the Study:

To review the current understanding of depression in the workplace.
To identify at-risk populations for workplace depression.
To explore challenges and future directions for managing depression in occupational settings.

Main Methods:

Review of clinical research with occupational samples.
Analysis of organizational psychology models.
Examination of employer perspectives on depression management.

Main Results:

Growing recognition of depression's prevalence and negative impact.
Better understanding of risk factors and overlap with occupational stress.
Identification of barriers to mitigation, including stigma and lack of effective interventions.

Conclusions:

Workplace depression poses significant challenges for employers.
Stigma and uncertainty about cost-effectiveness hinder treatment.
Future directions should focus on developing and implementing effective workplace interventions.