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Primary systemic therapy for operable breast cancer.

E D Anderson1, A P Forrest, R A Hawkins

  • 1University Department of Surgery, Royal Infirmary, Edinburgh, UK.

British Journal of Cancer
|April 1, 1991
PubMed
Summary
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Primary systemic therapy for operable breast cancer showed promising results. Endocrine therapy was effective for estrogen receptor-positive tumors, while cytotoxic therapy benefited others, leading to high survival and low relapse rates.

Area of Science:

  • Oncology
  • Medical treatment of breast cancer

Background:

  • Operable breast cancer (≥4 cm) requires effective primary systemic therapy before surgery.
  • Assessing treatment response is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of primary systemic therapy in operable breast cancer patients.
  • To correlate treatment response with estrogen receptor status and therapy type.

Main Methods:

  • Eighty-eight patients with operable breast cancer received 12 weeks of primary systemic therapy.
  • Response was assessed by tumor volume changes; surgery followed.
  • Endocrine therapy was used for ER-positive tumors; cytotoxic therapy for ER-negative or resistant cases.

Main Results:

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  • 39% response rate with endocrine therapy in ER-positive (≥20 fmol) tumors.
  • 72% response rate with cytotoxic therapy in ER-negative or endocrine-resistant tumors.
  • 3-year overall survival was 86%; 81% remained free from local relapse.

Conclusions:

  • Primary systemic therapy, tailored by ER status, demonstrates significant efficacy in operable breast cancer.
  • The observed outcomes support further investigation through controlled randomized trials against standard management.