Tonic and phasic pyloric activity in response to CCK-octapeptide
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Updated: Jul 7, 2026

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Frank K Friedenberg1, Joshua Desipio, Annapurna Korimilli
1Department of Medicine, Section of Gastroenterology, Temple University Hospital, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA. frank.friedenberg@temple.edu
Background:
The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide.
Methods:
Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 microg kg(-1) h(-1).
Results:
Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 +/- 2.1 to 9.9 +/- 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 microg kg(-1) h(-1) dose increased tonic pressure (8.8 +/- 1.4 to 17.6 +/- 2.0 mmHg; P = 0.01) as compared with the 0.02 microg kg(-1) h(-1) dose (4.7 +/- 0.7 to 7.3 +/- 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 +/- 28.4 mmHg and their frequency was 4.9 +/- 1.1 contractions min(-1).
Conclusions:
CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 mug kg(-1) h(-1) is greater than the response to 0.02 mug kg(-1) h(-1).
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