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[Early feeding in infancy and atopic dermatitis - a prospective observational study]

I Nentwich1, A Pazdírková, J Lokaj

  • 1Institut für klinische Immunologie und Allergologie der Masaryk-Universität, Brno, Tschechien.

Klinische Padiatrie
|February 14, 2008
PubMed

Insights

For high-risk infants, exclusive breastfeeding and hypoallergenic formula (HA) showed comparable atopic dermatitis (AD) rates in the first two years. However, HA-fed infants had greater weight gain by six months.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Science
  • Dermatology

Context:

  • Primary prevention of allergic diseases in high-risk infants often involves hypoallergenic infant formulas (HA) when breastfeeding is insufficient.
  • Understanding the long-term effects of infant nutrition on allergic disease development is crucial for public health guidelines.

Purpose:

  • To investigate the preventive effect of breastfeeding versus HA-nutrition on atopic dermatitis (AD) in high-risk infants up to two years of age.
  • To monitor weight gain and weight increase in infants fed with HA compared to breastfed infants.

Summary:

  • A study followed 174 high-risk newborns, comparing exclusively breastfed infants (n=45) with those primarily fed HA (n=61).
  • At six months, HA-fed infants showed significantly higher body weight and weight increase compared to breastfed infants.
  • The incidence of AD and SCORAD scores were comparable between groups at 6 to 24 months. Milk-specific IgE and BLG-specific PBMC proliferation did not predict AD development.

Impact:

  • Nutritional interventions with HA formulas do not appear to increase the risk of AD in high-risk infants compared to breastfeeding.
  • HA-fed infants exhibit accelerated weight gain in early infancy, which warrants consideration in growth monitoring.
  • Biomarkers like IgE and PBMC proliferation are not reliable predictors for AD development in this high-risk population, suggesting complex etiological factors.
Abstract

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