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Updated: Jul 7, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
Published on: May 31, 2013
RNACluster: An integrated tool for RNA secondary structure comparison and clustering
1James D. Watson Institute of Genomic Science, Zhejiang University, Hangzhou 310008, China.
Abstract:
RNA structure comparison is a fundamental problem in structural biology, structural chemistry, and bioinformatics. It can be used for analysis of RNA energy landscapes, conformational switches, and facilitating RNA structure prediction. The purpose of our integrated tool RNACluster is twofold: to provide a platform for computing and comparison of different distances between RNA secondary structures, and to perform cluster identification to derive useful information of RNA structure ensembles, using a minimum spanning tree (MST) based clustering algorithm. RNACluster employs a cluster identification approach based on a MST representation of the RNA ensemble data and currently supports six distance measures between RNA secondary structures. RNACluster provides a user-friendly graphical interface to allow a user to compare different structural distances, analyze the structure ensembles, and visualize predicted structural clusters.
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