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04:28
Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization
Published on: May 18, 2018
Hormonal, electrolyte, and renal responses to exercise are intensity dependent
B J Freund1, E M Shizuru, G M Hashiro
1Department of Clinical Investigation, Tripler Army Medical Center, Honolulu, Hawaii 96859-5000.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 1, 1991
Summary
Exercise intensity impacts kidney function. Lower intensity exercise may increase urine flow due to atrial natriuretic peptide, while higher intensities reduce renal function via hormonal changes.
Area of Science:
- Exercise Physiology
- Renal Physiology
- Endocrinology
Background:
- Renal responses to exercise are intensity-dependent.
- Mechanisms underlying these responses require further investigation.
Purpose of the Study:
- To investigate renal and hormonal responses to varying exercise intensities.
- To elucidate the mechanisms behind exercise-induced changes in renal function.
Main Methods:
- Eight healthy males performed 20-min submaximal exercise bouts at 25%, 40%, 60%, and 80% of maximal oxygen consumption.
- Measured urine flow, osmotic clearance, glomerular filtration rate, and sodium excretion.
- Assessed plasma levels of vasopressin (ADH), aldosterone, plasma renin activity, and atrial natriuretic peptide.
Main Results:
- Urine flow, glomerular filtration rate, and sodium excretion increased at 25% workload but decreased at higher intensities.
- Plasma vasopressin, aldosterone, and renin activity increased with exercise intensity, becoming significant at >=60% workload.
- Atrial natriuretic peptide significantly elevated at all workloads, while vasopressin decreased at 25% workload.
Conclusions:
- Atrial natriuretic peptide and vasopressin suppression may explain increased urine flow at low exercise intensity.
- Higher exercise intensities lead to reduced renal function, mediated by hormonal changes.
- Exercise intensity is a critical determinant of renal and hormonal responses during physical activity.
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