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Updated: Jul 7, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
Published on: February 4, 2021
Pigment epithelium-derived factor (PEDF): drug developmental challenges ahead for a budding anti-angiogenic
1Department of Orthopaedics, St. Vincent's Hospital, Melbourne, Australia. crispin.dass@svhm.org.au
Abstract:
One of the most potent anti-angiogenic biological discovered to date, pigment epithelium-derived factor (PEDF) is fast becoming an exciting and promising lead candidate. Recent studies have shown that even shortened versions of the protein can serve as therapeutic agents with similar activity as the parent molecule. The next obvious challenge is to find ways to deliver this molecule in vivo with enhanced pharmacodynamics and reduced toxicity. Several methods to achieve this are proposed.
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