Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 7, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Emulsifying properties of biodegradable polylactide-grafted dextran copolymers.

J Raynaud1, B Choquenet, E Marie

  • 1Laboratoire de Chimie Physique Macromoléculaire, UMR 7568, CNRS-Nancy-University, ENSIC, BP 20451, 54001 Nancy Cedex, France.

Biomacromolecules
|February 15, 2008
PubMed
Summary

Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized and showed tunable solubility and emulsifying properties. These copolymers stabilized emulsions and were used to create polyacrylamide hydrogel nanoparticles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary lipid droplet size and phospholipids modulate lipid digestion and absorption in early life nutrition, an in vitro study.

Food chemistry·2026
Same author

Magnetic imaging under high pressure with a spin-based quantum sensor integrated in a van der Waals heterostructure.

Nature communications·2025
Same author

Proof of concept and design of an externally controlled trial for patients with gastro-enteropancreatic neuroendocrine carcinomas based on the randomized phase II BEVANEC trial.

European journal of cancer (Oxford, England : 1990)·2025
Same author

Nuclear Magnetic Resonance with a Levitating Microparticle.

Physical review letters·2024
Same author

Isotopic Control of the Boron-Vacancy Spin Defect in Hexagonal Boron Nitride.

Physical review letters·2023
Same author

Optically Active Spin Defects in Few-Layer Thick Hexagonal Boron Nitride.

Physical review letters·2023

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Amphiphilic copolymers are crucial for stabilizing emulsions and creating advanced materials.
  • Dextran-grafted polylactide (Dex-g-PLA) copolymers offer tunable properties based on their composition.
  • Controlled synthesis is key to achieving desired copolymer architectures and functionalities.

Purpose of the Study:

  • To synthesize amphiphilic Dex-g-PLA copolymers with controlled architectures.
  • To investigate the emulsifying properties and emulsion stabilization mechanisms of Dex-g-PLA copolymers.
  • To explore the application of Dex-g-PLA in the preparation of polyacrylamide hydrogel nanoparticles via miniemulsion.

Main Methods:

  • Three-step synthesis involving dextran silylation, lactide ring-opening polymerization, and deprotection.

More Related Videos

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Related Experiment Videos

Last Updated: Jul 7, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

  • Solubility studies to determine water or organic solvent compatibility.
  • Emulsion stabilization experiments (direct and inverse) and droplet size analysis.
  • Ostwald ripening mechanism investigation for emulsion aging.
  • Inverse miniemulsion copolymerization using Dex-g-PLA as a stabilizer.

    • Main Results:

    • Dex-g-PLA copolymers exhibited tunable solubility in water or organic solvents based on PLA content.
    • Copolymers effectively stabilized both direct and inverse emulsions, with droplet size dependent on stabilizer concentration.
    • Ostwald ripening was identified as the primary aging mechanism for both emulsion types.
    • Polyacrylamide hydrogel nanoparticles were successfully synthesized using Dex-g-PLA in inverse miniemulsion.

    Conclusions:

    • Amphiphilic Dex-g-PLA copolymers are versatile stabilizers for emulsions with tunable properties.
    • The synthesis route allows for precise control over copolymer architecture, influencing solubility and emulsification.
    • Dex-g-PLA copolymers facilitate the formation of polyacrylamide hydrogel nanoparticles, demonstrating their utility in nanotechnology.