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Related Experiment Video

Updated: Jul 7, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Simultaneous decrease of plasma obestatin and ghrelin levels after a high-carbohydrate breakfast in healthy women.

D Sedláčková¹, I Dostálová, V Hainer

¹Institute of Endocrinology, Prague, Czech Republic.

Physiological Research

|February 15, 2008

Summary

This study shows that obestatin and ghrelin levels decrease after a high-carbohydrate meal in healthy women. These findings explore the relationship between these appetite-regulating peptides post-meal.

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Area of Science:

Endocrinology
Gastroenterology
Metabolism

Background:

Ghrelin, a stomach-derived peptide, stimulates appetite.
Obestatin, derived from the same precursor as ghrelin, was initially thought to inhibit ghrelin's effects.
The postprandial (after-meal) behavior of obestatin and its relationship with ghrelin in humans were not well understood.

Purpose of the Study:

To investigate the postprandial response of obestatin, ghrelin (total, acyl, and desacyl forms), and Neuropeptide Y (NPY) after a high-carbohydrate breakfast in healthy women.
To understand the interplay between these hormones in regulating appetite after food intake.

Main Methods:

Eight healthy women consumed a standardized high-carbohydrate breakfast (1604 kJ).
Blood samples were collected at multiple time points (pre-meal, 30, 60, 90, 120, 150 minutes post-meal).
Plasma concentrations of obestatin, total ghrelin, acyl ghrelin, desacyl ghrelin, and NPY were measured.

Main Results:

Plasma obestatin concentrations significantly decreased post-meal, reaching lowest levels at 90 minutes.
Total ghrelin concentrations also significantly decreased, with nadir at 120 minutes.
Acyl and desacyl ghrelin levels decreased at 30 and 60 minutes, respectively. NPY levels were lower at 90 and 150 minutes post-meal.

Conclusions:

Postprandial plasma obestatin concentrations decrease similarly to ghrelin levels after a high-carbohydrate meal in healthy young women.
This suggests a coordinated response of these peptides following nutrient intake.
Further research is needed to fully elucidate the roles of obestatin and ghrelin in human appetite regulation.