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Related Experiment Video

Updated: Jul 7, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

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Androgenic anabolic steroids also impair right ventricular function.

Erdem Kasikcioglu, Huseyin Oflaz, Berrin Umman

International Journal of Cardiology

|February 15, 2008

Summary

Chronic anabolic steroid use impairs heart function. This study found that anabolic steroid-using bodybuilders showed reduced diastolic function in both ventricles compared to non-users.

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Area of Science:

Cardiology
Sports Medicine
Pharmacology

Background:

Chronic anabolic steroid use is known to negatively affect left ventricular function.
The impact of anabolic steroids on right ventricular function, crucial for overall cardiac health, remains understudied.

Purpose of the Study:

To investigate the chronic effects of androgenic anabolic steroid (AAS) usage on right heart remodeling in athletes.
To assess the diastolic function of both ventricles in AAS-using bodybuilders.

Main Methods:

Comparative analysis of cardiac function in three groups: AAS-using bodybuilders, drug-free bodybuilders, and sedentary individuals.
Evaluation of diastolic velocities in both ventricles.

Main Results:

Bodybuilders using AAS demonstrated significantly lower diastolic velocities in both the left and right ventricles compared to drug-free and sedentary groups.
Evidence of depressed diastolic function in both ventricles among AAS users.

Conclusions:

Chronic androgenic anabolic steroid use negatively impacts the diastolic function of both ventricles.
This suggests a potential for widespread cardiac dysfunction with long-term AAS abuse in athletes.