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Related Experiment Video

Updated: Jul 7, 2026

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

Published on: August 15, 2025

Relation between aortic cross-clamp time and mortality--not as straightforward as expected.

Torsten Doenst¹, Michael A Borger, Richard D Weisel

¹Division of Cardiovascular Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery

|February 15, 2008

Summary

Aortic cross-clamp time predicts mortality in cardiac surgery patients with preserved heart function. However, it does not predict mortality in patients with poor heart function, who face high risks even with short clamp times.

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A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

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Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

Area of Science:

Cardiovascular Surgery
Cardiac Anesthesia

Background:

Modern cardio-protection techniques have reduced focus on aortic cross-clamp (XCL) times.
Patients with impaired cardiac function face increased perioperative risk, potentially due to heightened susceptibility to myocardial ischemia.

Purpose of the Study:

To investigate the association between aortic cross-clamp times and perioperative mortality.
To compare this association in patients with preserved versus poor left ventricular function.

Main Methods:

Analysis of predictors of operative mortality in 27,215 cardiac surgery patients (1990-2003) with aortic cross-clamping.
Exclusion of patients with XCL times >120 minutes to mitigate confounding factors.
99.8% of included patients received antegrade, retrograde, or combined blood cardioplegia.

Main Results:

Overall mortality was 2.2%.
Aortic cross-clamp time independently predicted mortality in patients with left ventricular ejection fraction (LVEF) >40%.
Aortic cross-clamp time did not predict mortality in patients with LVEF <40%, with high mortality observed even at short cross-clamp times (1-30 min).

Conclusions:

Aortic cross-clamp time remains an independent predictor of mortality in cardiac surgery patients with preserved preoperative contractile function.
The lack of predictive value in patients with low ejection fraction is attributed to high mortality rates associated with short cross-clamp durations in this group.