Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Atomic Nuclei: Nuclear Spin State Overview

Atomic Nuclei: Nuclear Spin State Overview

NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of one, the...

Spin–Spin Coupling Constant: Overview

Spin–Spin Coupling Constant: Overview

In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must have a...

Atomic Nuclei: Nuclear Spin

Atomic Nuclei: Nuclear Spin

All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...

¹H NMR Signal Multiplicity: Splitting Patterns

¹H NMR Signal Multiplicity: Splitting Patterns

When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

In the AX proton spin system, proton A can sense the two spin states of a coupled proton X, resulting in a doublet NMR signal with two peaks of equal (1:1) intensity. When proton A is coupled to two equivalent protons (AX2 spin system), the spin states of each X can be aligned with or against the external field, creating three possible scenarios. This results in a 1:2:1 triplet signal, where the central peak corresponds to the chemical shift of A and is twice as large or intense as the others.

Atomic Nuclei: Nuclear Spin State Population Distribution

Atomic Nuclei: Nuclear Spin State Population Distribution

Near absolute zero temperatures, in the presence of a magnetic field, the majority of nuclei prefer the lower energy spin-up state to the higher energy spin-down state. As temperatures increase, the energy from thermal collisions distributes the spins more equally between the two states. The Boltzmann distribution equation gives the ratio of the number of spins predicted in the spin −½ (N−) and spin +½ (N+) states.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Response to: 'Long term night shift work, genetic predisposition, and risk of incident asthma: a prospective study'.

QJM : monthly journal of the Association of Physicians·2024

Same author

Long-term night shift work, genetic predisposition and risk of incident asthma: a prospective cohort study.

QJM : monthly journal of the Association of Physicians·2024

Same author

Preoperative BMI and Hb levels are important predictors of massive bleeding in liver transplant patients.

European review for medical and pharmacological sciences·2024

Same author

Mass spectrometry-based metabolic profiling for identification of biomarkers related to footpad dermatitis in ducks.

British poultry science·2023

Same author

Efficacy of clonidine in the treatment of children with tic disorder co-morbid with attention deficit hyperactivity disorder.

European review for medical and pharmacological sciences·2023

Same author

CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.

Journal of endocrinological investigation·2023

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Through-space MP-CPMAS experiments between spin-1/2 and half-integer quadrupolar nuclei in solid-state NMR.

B Hu¹, J P Amoureux, J Trébosc

¹UCCS, CNRS-8181, Lille University, Fr-59652 Villeneuve d'Ascq, France.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|February 15, 2008

Summary

This summary is machine-generated.

A new cross-polarization magic angle spinning (CPMAS) method enables solid-state 2D HETCOR spectra for spin-1/2 and quadrupolar nuclei. This technique offers improved robustness, efficiency, and ease of setup compared to standard methods.

More Related Videos

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

Related Experiment Videos

Last Updated: Jul 7, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

Area of Science:

Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy
Materials science
Chemistry

Background:

Heteronuclear Correlation (HETCOR) spectroscopy is crucial for determining molecular structure in solids.
Acquiring HETCOR spectra between spin-1/2 and half-integer quadrupolar nuclei in the solid state presents significant challenges.
Existing methods often suffer from limitations in efficiency, robustness, and experimental setup complexity.

Purpose of the Study:

To introduce a novel Cross-Polarization Magic Angle Spinning (CPMAS) technique for solid-state 2D HETCOR spectroscopy.
To facilitate HETCOR experiments involving both spin-1/2 and half-integer quadrupolar nuclei.
To overcome the limitations of existing methods for heteronuclear correlation in solid samples.

Main Methods:

Development of a new CPMAS method utilizing rotor-synchronized selective pulses on the quadrupolar nucleus.
Application of continuous-wave Radio Frequency (RF) irradiation on the spin-1/2 nucleus to generate heteronuclear dipolar coherences.
Implementation of through-space 2D HETCOR acquisition in the solid state.

Main Results:

Successful acquisition of through-space 2D HETCOR spectra between spin-1/2 and half-integer quadrupolar nuclei.
Demonstration of enhanced robustness and efficiency compared to standard CPMAS transfer techniques.
Validation of the method's ease of setup and implementation.

Conclusions:

The presented CPMAS method provides a more effective and accessible approach for solid-state heteronuclear correlation spectroscopy.
This advancement expands the capabilities of NMR spectroscopy for characterizing complex solid materials.
The new technique is expected to benefit researchers in materials science, chemistry, and related fields.