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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[How to evaluate body composition in chronic kidney disease?]
Marie Essig1, François Vrtovsnik
1Service de Néphrologie, Hôpital Bichat, Paris, France. essig@bichat.inserm.fr
Nephrologie & Therapeutique
|February 15, 2008
Summary
Chronic kidney disease (CKD) causes body composition changes, leading to malnutrition and cardiovascular risks. Combining dual energy X-ray absorptiometry (Dexa) and impedancemetry accurately assesses body cell mass, crucial for nutritional status in CKD patients.
Area of Science:
- Nephrology and Human Physiology
- Biomedical Engineering
- Nutritional Science
Context:
- Chronic kidney disease (CKD) onset is linked to significant body composition alterations.
- These changes stem from sodium imbalance and heightened protein catabolism, impacting nutritional status.
- Malnutrition and increased cardiovascular risk are direct consequences requiring precise analysis.
Purpose:
- To evaluate methods for accurately analyzing body composition in CKD patients.
- To identify the most suitable techniques for measuring key physiological compartments.
- To determine if combining dual energy X-ray absorptiometry (Dexa) and spectroscopic impedancemetry can effectively assess body cell mass.
Summary:
- Current body composition analysis methods have limitations in measuring all five physiological compartments (extracellular fluid, intracellular fluid, body cell mass, bone mass, fat mass).
- Dual energy X-ray absorptiometry (Dexa) excels at measuring fat, bone, and lean mass, while impedancemetry is effective for body fluids.
- The synergistic combination of Dexa and impedancemetry enables the calculation of body cell mass, a vital indicator of nutritional status in CKD.
Impact:
- Provides a more accurate method for assessing nutritional status in CKD patients.
- Highlights the combined potential of Dexa and impedancemetry for comprehensive body composition analysis.
- Improves understanding of body composition changes in CKD, potentially guiding therapeutic interventions and improving patient outcomes.
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