Related Experiment Video
Updated: Jul 7, 2026

A Mouse Model of Lumbar Spine Instability
Published on: April 23, 2021
The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental
1Department of Neurosurgery, Saint-Joseph University and Hôtel-Dieu de France, Beirut, Lebanon. rrahme@waln.org
Abstract:
Two decades following their description, the significance of Modic vertebral endplate and marrow changes remains a matter of debate. These changes are closely related to the normal degenerative process affecting the lumbar spine, and their prevalence increases with age. However, the exact pathogenesis underlying these changes and their relation to segmental instability of the lumbar spine and to low back pain remain unclear. In this paper, we review the literature relevant to this topic and discuss the currently available evidence regarding the pathologic and clinical significance of Modic changes.
Related Concept Videos
Degenerative Disc Disease ll: Pathophysiology
Degenerative Disc Disease I: Introduction
Herniated Intervertebral Disc l: Introduction
General Structure of a Vertebra
Vertebral Column: Regions and Curvature
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...
Structural Joints: Cartilaginous Joints
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
