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Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters (CNiFERs) for Optical Detection of Neurotransmitters In Vivo
Published on: May 12, 2016
Noninvasive molecular neuroimaging using reporter genes: part II, experimental, current, and future applications
T F Massoud1, A Singh, S S Gambhir
1Department of Radiology, Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. tfm23@radiol.cam.ac.uk
AJNR. American Journal of Neuroradiology
|February 15, 2008
Summary
Reporter genes enable molecular imaging of the brain in living subjects, advancing the study of gene expression and neuropathology. Continued innovation promises future clinical applications for neurologic diseases.
Area of Science:
- Neuroscience
- Molecular Biology
- Medical Imaging
Background:
- Reporter genes are crucial for visualizing biological processes.
- Molecular imaging offers non-invasive insights into the central nervous system.
- Understanding gene expression is key to studying brain function and disease.
Purpose of the Study:
- To review strategies and applications of reporter genes in brain molecular imaging.
- To highlight the utility of reporter gene imaging in preclinical research.
- To discuss the future potential of this technology in neurology.
Main Methods:
- Review of existing literature on reporter gene strategies.
- Analysis of applications in laboratory animal models.
- Discussion of advancements in reporter gene technology and detection.
Main Results:
- Reporter gene imaging facilitates monitoring of gene expression in vivo.
- Applications include studying gene-targeted cells, gene therapies, and transgenic models.
- Complex molecular interactions within the central nervous system can be investigated.
Conclusions:
- In vivo reporter gene imaging is a versatile tool for neuroscience research.
- Enhanced reporters and detection technologies will improve sensitivity and selectivity.
- This technique holds potential for understanding neuropathology and clinical management of neurologic diseases.
