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HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease

Najat Mahdi1, Khadija Al-Ola, Abeer M Al-Subaie

  • 1Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain.

Clinical and Vaccine Immunology : CVI
|February 15, 2008
PubMed

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

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