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Related Experiment Videos

Is breast conservation after local recurrence feasible?

J M Kurtz1, J Jacquemier, R Amalric

  • 1Radiation Oncology Division, University Hospital, Geneva, Switzerland.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1991
PubMed
Summary

Wide excision for recurrent breast cancer offers good local control, especially for late recurrences. Achieving negative resection margins is crucial for successful conservative salvage surgery.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Breast conserving treatment (BCT) is standard for early breast cancer.
  • Intramammary recurrences after BCT require effective salvage strategies.
  • Conservative approaches aim to preserve breast tissue while achieving local control.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of wide excision for intramammary recurrences after BCT.
  • To identify factors influencing local control after salvage surgery.
  • To assess wide excision as an alternative to mastectomy for recurrent breast cancer.

Main Methods:

  • Clinicopathologic study of 50 patients undergoing wide excision for intramammary recurrence.
  • Median follow-up of 51 months.

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  • Cox multivariate analysis of 18 parameters to determine predictors of local control.

    • Main Results:

    • 16 (32%) patients experienced second local failures, with a 5-year local control rate of 62%.
    • Disease-free interval (DFI) and resection margins were significant predictors of local control.
    • 5-year local control was 92% for recurrences >5 years DFI vs. 49% for shorter intervals; 73% for negative margins vs. 36% for positive/indeterminate margins.
    • Local control was independent of tumor features and patient demographics.

    Conclusions:

    • Wide excision is a satisfactory salvage option for intramammary recurrences, particularly for late recurrences.
    • Negative resection margins are essential for successful local control.
    • Further research is needed to refine patient selection for this conservative approach.