Related Experiment Video
Updated: Jul 7, 2026
07:52
Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
Published on: August 14, 2014
Aerobic exercise affects C57BL/6 murine intestinal contractile function.
Claudio Andre Barbosa de Lira1, Rodrigo Luiz Vancini, Silvia Saiuli Miki Ihara
1Department of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
European Journal of Applied Physiology
|February 15, 2008
Summary
Moderate exercise training impacts intestinal function. Endurance exercise impairs ileum contractility but protects against oxidative stress, showing exercise
Area of Science:
- Physiology
- Exercise Science
- Gastroenterology
Background:
- Moderate aerobic exercise may induce ischemia-reperfusion events in the intestine.
- Understanding exercise effects on intestinal contractility is crucial for health.
Purpose of the Study:
- To investigate the influence of moderate exercise training on intestinal contractility.
- To assess the impact of endurance exercise on ileum function and oxidative stress.
Main Methods:
- C57BL/6 mice underwent a moderate treadmill running program (55 days).
- Intestinal contractility was measured using electro- and pharmacomechanical stimulations.
- Ileum lipid peroxidation was assessed to evaluate oxidative stress.
Main Results:
- Exercise training improved physical performance and heart mass-to-body mass ratio.
- A significant reduction in ileum contractility efficacy was observed after 55 days.
- Ileum lipid peroxidation decreased significantly after 10 days and remained low.
Conclusions:
- Moderate aerobic exercise training impairs murine ileum contractility.
- Endurance exercise offers a protective effect against intestinal oxidative stress.
- The ileum is a significant target organ for moderate aerobic exercise programs.
