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Updated: Jul 7, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Surgical issues and preoperative systemic therapy.

Lisa A Newman¹

¹Breast Care Center, University of Michigan, Ann Arbor, MI 48109-0932, USA.

Cancer Treatment and Research

|February 16, 2008

Summary

This summary is machine-generated.

Neoadjuvant chemotherapy helps shrink locally advanced breast cancer, improving surgical options and allowing breast conservation. This approach also assesses treatment effectiveness, benefiting selected early-stage cases.

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Last Updated: Jul 7, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Area of Science:

Oncology
Surgical Oncology
Breast Cancer Research

Background:

Neoadjuvant chemotherapy is standard for locally advanced breast cancer, aiming for disease downstaging and improved surgical outcomes.
It can render previously unresectable tumors operable and potentially enable breast-conserving surgery (lumpectomy).

Purpose of the Study:

To explore the expanded application of neoadjuvant chemotherapy in selected early-stage breast cancer cases.
To highlight the benefits of neoadjuvant chemotherapy in improving candidacy for breast conservation surgery.

Main Methods:

Review of neoadjuvant chemotherapy protocols for breast cancer.
Emphasis on surgical considerations including diagnostic biopsies, preoperative planning (tumor bed marking), and imaging for surgical decision-making.

Main Results:

Neoadjuvant chemotherapy facilitates downstaging, enhancing operability and enabling less extensive surgical procedures like lumpectomy.
Assessment of chemosensitivity is a key benefit, guiding treatment and surgical planning.

Conclusions:

Neoadjuvant chemotherapy offers significant benefits for both locally advanced and selected early-stage breast cancers.
Optimal utilization requires meticulous surgical planning, including precise tumor marking and comprehensive imaging to guide lumpectomy versus mastectomy decisions.